Does The Witcher 2: Assassins of Kings run on Mac?

Yes — The Witcher 2: Assassins of Kings has a native Mac version.

Start there, not with us: Steam lists a macOS build of The Witcher 2: Assassins of Kings and your Steam purchase includes it, so install that first. We would rather tell you that than sell you a compatibility layer you have no use for. If the native build turns out to be an old one that no longer runs on modern macOS, Pixel Port runs the Windows version instead.